Research
Projects

Objectives

• — SNP-level analysis of genes involved in a chosen micronutrient pathway
• — In silico exploration of gene-diet interactions relevant to a metabolic condition
• — Pathway-level analysis of nutrient-related genes and a specific health outcome
• — Investigating nutrigenetic variation associated with a chosen dietary trait
• — Population-level profiling of nutrient-metabolism genes using public datasets

Technologies

Objectives

• — Differential expression analysis from an RNA-Seq dataset in a disease context
• — De novo assembly and quality assessment of a bacterial genome from sequencing reads
• — Variant identification and annotation from exome-level sequencing data
• — Read quality assessment and preprocessing benchmarking across sequencing runs
• — Functional annotation of assembled transcripts from a non-model organism

Technologies

Objectives

• — Comparative microbiome analysis between two contrasting host or environment groups
• — Metagenomic profiling of an environmental sample dataset
• — Taxonomic and functional characterization of a chosen microbial community
• — Diversity assessment across a set of related environmental samples
• — Investigating community shifts associated with a specific treatment or condition

Technologies

Objectives

• — Guide RNA design for targeted knockout of a disease-associated gene
• — Off-target risk assessment for a proposed CRISPR editing strategy
• — In silico validation of candidate target sites in a model organism genome
• — Comparative analysis of CRISPR-relevant sequence motifs across bacterial genomes
• — Evaluation of predicted editing efficiency for a chosen guide RNA design

Technologies

Objectives

• — Structure-based design of inhibitors for a cancer-relevant enzyme target
• — Pharmacophore-based screening for a metabolic disease target
• — Docking-based evaluation of natural compound analogs against an inflammatory target
• — Virtual screening of marine-derived compounds for antimicrobial potential
• — Design considerations for selective enzyme inhibitors in a chosen target class

Technologies

Objectives

• — Epitope-based vaccine candidate design for a bacterial pathogen of interest
• — Multi-epitope construct design against a selected viral target
• — B-cell and T-cell epitope mapping of a disease-relevant viral protein
• — Simulated immune response evaluation of a candidate vaccine construct
• — Population coverage assessment of a proposed epitope-based vaccine

Technologies

Objectives

• — Virtual screening of a natural compound library against a chosen bacterial target
• — Structure-activity relationship modelling for a compound class of interest
• — Drug-likeness and ADMET profiling of candidate molecules from a plant source
• — Descriptor-based clustering of a public compound dataset
• — Filter-based prioritization of phytochemical candidates for further study

Technologies

Objectives

• — Functional characterization of an uncharacterized protein sequence
• — Comparative genome analysis across related bacterial species
• — Computational prediction of regulatory RNA targets in disease-relevant genes
• — Protein interaction network analysis for a chosen disease pathway
• — Mining expression data for stress- or condition-responsive gene sets

Technologies

Objectives

• — Sequence 20 marine organism samples
• — Publish a year-one findings report
• — Build a public reference dataset

Technologies